Surgical patients who received the flu vaccine during their hospital stay did not have an increased risk of emergency department visits or subsequent hospitalizations in the week following discharge, compared with surgical patients who did not receive the vaccine. The new study from Kaiser Permanente, published in the Annals of Internal Medicine, also found that compared with unvaccinated surgical patients, vaccinated surgical patients did not have an increased risk of fever nor did they have an increased number of laboratory tests checking for infection.
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"Historically, there has been concern among surgeons that vaccinating patients while they are in the hospital can contribute to increased risk of vaccine-related fever or muscle pain, which might be incorrectly attributed to surgical complications," explained Sara Y. Tartof, PhD, MPH, study lead author, Kaiser Permanente Southern California Department of Research & Evaluation. "There have been no data to support that concern. In fact, our study findings show hospital stays are a fine time to vaccinate patients, particularly those who are older and at high risk of complications due to the flu."
The flu is a highly contagious respiratory infection that can cause serious complications, hospitalizations and, in some cases, even death. Some people, such as older adults, young children and people with certain health conditions, are at high risk for serious complications. In addition to recommending annual flu vaccination for people 6 months of age and older, the Centers for Disease Control and Prevention recommends that hospitalized patients who are eligible receive the flu vaccine before discharge.
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In this study, researchers analyzed the health records of Kaiser Permanente members in Southern California who were eligible for flu vaccination in the 2010 through 2013 flu seasons. Those seasons were defined as starting Sept. 1 and ending March 31. Of the 81,647 surgeries evaluated, 34 percent involved patients who did not receive the flu vaccine during the flu season, while 8 percent involved patients who had vaccinations during the hospital stay. The remaining surgeries included patients who had vaccine documented either before hospital admission or after discharge from the hospital. Of those surgeries involving patients who were vaccinated during their hospitalization, the majority were vaccinated on the day of discharge (78 percent).
The new blood test detects cell death in specific tissues by combining two important biological principles. First, dying cells release fragmented DNA to the circulation, where it travels for a short time. This fact has been known for decades; however since the DNA sequence of all cells in the body is identical, it has not been possible to determine the tissue of origin of circulating DNA, and simple measurements of the amount of circulating DNA is of very limited use. The second principle is that the DNA of each cell type carries a unique chemical modification called methylation. Methylation patterns of DNA account for the identity of cells (the genes that they express), are similar among different cells of the same type and among individuals, and are stable in healthy and disease conditions. For example, the DNA methylation pattern of pancreatic cells differs from the pattern of all other cell types in the body.
The researchers have identified multiple DNA sequences that are methylated in a tissue-specific manner (for example, unmethylated in DNA of neurons and methylated elsewhere), and can serve as biomarkers for the detection of DNA derived from each tissue. They then developed a method to detect these methylated patterns in DNA circulating in blood, and demonstrated its utility for identifying the origins of circulating DNA in different human pathologies, as an indication of cell death in specific tissues. They were able to detect evidence for pancreatic beta-cell death in the blood of patients with new-onset type 1 diabetes, oligodendrocyte death in patients with relapsing multiple sclerosis, brain cell death in patients after traumatic or ischemic brain damage, and exocrine pancreas cell death in patients with pancreatic cancer or pancreatitis.
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cay an xoa bao nhieu tien 1kg
"Historically, there has been concern among surgeons that vaccinating patients while they are in the hospital can contribute to increased risk of vaccine-related fever or muscle pain, which might be incorrectly attributed to surgical complications," explained Sara Y. Tartof, PhD, MPH, study lead author, Kaiser Permanente Southern California Department of Research & Evaluation. "There have been no data to support that concern. In fact, our study findings show hospital stays are a fine time to vaccinate patients, particularly those who are older and at high risk of complications due to the flu."
The flu is a highly contagious respiratory infection that can cause serious complications, hospitalizations and, in some cases, even death. Some people, such as older adults, young children and people with certain health conditions, are at high risk for serious complications. In addition to recommending annual flu vaccination for people 6 months of age and older, the Centers for Disease Control and Prevention recommends that hospitalized patients who are eligible receive the flu vaccine before discharge.
cay an xoa kho
In this study, researchers analyzed the health records of Kaiser Permanente members in Southern California who were eligible for flu vaccination in the 2010 through 2013 flu seasons. Those seasons were defined as starting Sept. 1 and ending March 31. Of the 81,647 surgeries evaluated, 34 percent involved patients who did not receive the flu vaccine during the flu season, while 8 percent involved patients who had vaccinations during the hospital stay. The remaining surgeries included patients who had vaccine documented either before hospital admission or after discharge from the hospital. Of those surgeries involving patients who were vaccinated during their hospitalization, the majority were vaccinated on the day of discharge (78 percent).
The new blood test detects cell death in specific tissues by combining two important biological principles. First, dying cells release fragmented DNA to the circulation, where it travels for a short time. This fact has been known for decades; however since the DNA sequence of all cells in the body is identical, it has not been possible to determine the tissue of origin of circulating DNA, and simple measurements of the amount of circulating DNA is of very limited use. The second principle is that the DNA of each cell type carries a unique chemical modification called methylation. Methylation patterns of DNA account for the identity of cells (the genes that they express), are similar among different cells of the same type and among individuals, and are stable in healthy and disease conditions. For example, the DNA methylation pattern of pancreatic cells differs from the pattern of all other cell types in the body.
The researchers have identified multiple DNA sequences that are methylated in a tissue-specific manner (for example, unmethylated in DNA of neurons and methylated elsewhere), and can serve as biomarkers for the detection of DNA derived from each tissue. They then developed a method to detect these methylated patterns in DNA circulating in blood, and demonstrated its utility for identifying the origins of circulating DNA in different human pathologies, as an indication of cell death in specific tissues. They were able to detect evidence for pancreatic beta-cell death in the blood of patients with new-onset type 1 diabetes, oligodendrocyte death in patients with relapsing multiple sclerosis, brain cell death in patients after traumatic or ischemic brain damage, and exocrine pancreas cell death in patients with pancreatic cancer or pancreatitis.
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