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UIC's medical research endeavors span all sectors.
The University of Illinois at Chicago (UIC) is Chicago's only public research university, and their research covers a wide range of topics including - but not limited to - computer science, sustainability, bioengineering, health sciences, psychology, and education.
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According to their website, UIC aims to "affect the way we live."
In this article, however, we will focus our attention on medical advances, concentrating on just five of their recent projects. We also speak with some of the researchers responsible for these fresh ideas.
Gut bacteria's role in breast cancerThe role of gut bacteria in health and disease is a hot topic. Jun Sun, associate professor at UIC, and Tao Pan, from the University of Chicago, are investigating the role of gut bacteria in breast cancer.
Specifically, they are interested in a chemical called queuine. Queuine is produced by certain gut flora, absorbed through the intestine and circulated in the blood. Cells use queuine to modify transfer RNAs (tRNAs), which are adaptor molecules that link messenger RNA to the amino acid sequence of proteins. Queuine helps tRNAs to make proteins more accurately and efficiently.
Previous research has shown that abnormal levels of tRNA are linked to an increase in breast cancer risk. Because of this link, gut bacteria and queuine are under the spotlight for their potential role in breast cancer.
Medical News Today recently asked Sun what first excited her about gut bacteria. She said:
"I was first excited about how bacteria interact with host and environment. I am impressed that they are so smart; they have existed for millions of years and have intelligence we do not know. It is very interesting to consider the microbiome as a newly discovered organ and understand its novel roles in health and disease."
We also asked whether, if queuine is involved in breast cancer, it is possible that certain antibiotics might influence breast cancer risk. She replied:
"A previous study, published in JAMA in 2004, showed that 'use of antibiotics is associated with increased risk of incident and fatal breast cancer.' [...] It is possible that antibiotic use changes the profile/function of bacteria. We need more evidence to support this hypothesis."
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Sun's laboratory is currently looking at the role of the microbiome in a number of diseases, including inflammatory bowel diseases, infectious diseases, and amyotrophic lateral sclerosis.